Caryophyllene: A Terpene for Pain Relief

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Close up of a hand holding a cannabis plant

Close up of a hand holding a cannabis plant

Different cannabis users tend to prefer different strains due to their unique tastes and aromas. This noticeable difference in strains comes due to the terpenes found within them. Terpenes are aromatic compounds that are responsible for giving different plants their exclusive flavors. 

There are several types of terpenes, each of which is associated with a distinct taste and aroma. For instance, the Limonene terpene is associated with a citrusy aroma, while plants with Humulene as their dominant terpene carry more of a spicy and woody smell. 

In this article, we will specifically focus on one of the most popular cannabis terpenes, Caryophyllene, along with its properties, and benefits. We will also share a few favorite Caryophyllene-dominant cannabis strains with you. 

The Caryophyllene Terpene 

This individual terpene is known to interact with your body’s endocannabinoid system. Caryophyllene tends to attach itself to our body’s CB2 receptors (found in peripheral organs), which enables it to offer a broad range of medical benefits, including anti-inflammatory effects

The reason why it binds seamlessly to our body’s CB2 receptors is its molecular structure. The fact that it attaches to the CB2 receptors means that the body can benefit from the terpene’s medical benefits without the psychoactive effects. 

The psychoactive effects are triggered when a cannabinoid binds to the CB1 receptors, which are found in the central nervous system and the brain. For better comprehension, THC attaches to the CB1 receptors, which is why it leads to the psychoactive buzz.

Caryophyllene is often found in spices like black pepper, cinnamon, and cloves, among several others. It is also referred to as the stress-relieving terpene and can be found in a multitude of cannabis hybrids. Caryophyllene is also associated with anti-anxiety effects. It is why people seeking such medical benefits often root for the strains that contain this terpene.

Flavor Profile of Caryophyllene

As mentioned above, different terpenes are associated with different flavor and aromatic profiles. Caryophyllene is known for its spicy scent, which can be felt in several essential oils, including rosemary, basil, and black caraway. 

This terpene is also found in Ylang-Ylang essential oil, often used in perfumes to achieve a strong and spicy essence. 

Caryophyllene’s Properties

This terpene is known for its highly therapeutic properties due to its ability to bind with the body’s CB2 receptors. It has been a known antioxidant agent, anticancer, and antimicrobial. Several studies are underway to further understand the extent of benefits behind Caryophyllene. 

According to several current findings, this terpene has potential to bring the following benefits to the user: 

Pain Relief

One of the key reasons why users opt for Caryophyllene strains is that it contains pain-reducing properties. 

Anxiety Relief

Millions of people across the globe suffer from symptoms anxiety, and Caryophyllene has already become a go-to solution for many of them. A study from the Physiology and Behavior journal has revealed that this terpene can help in balancing the chemicals inside our bodies, which could lead to anxiety relief.

Another study also revealed that this terpene might also be beneficial against critical conditions like Parkinson’s disease. 


Caryophyllene may also express beneficial properties to combat cancer. Although more studies are required in this area, researchers believe that this terpene may be responsible for hindering the growth of cancer cells, which could help doctors effectively devise several cancer treatments.


This may be one of the common associations made between Caryophyllene and its therapeutic effects. Experts have concluded that this terpene contains properties that may well be anti-inflammatory. Initial research was done on this matter using subjected rats. It revealed that terpene is effective when it comes to reducing swelled lymph nodes.

Other Associations

Experts believe the Caryophyllene may be the perfect terpene when it comes to treating alcohol addiction. Furthermore, it has also been associated with the treatment of inflammatory bowel disease. 

In short, Caryophyllene may be one of the leading terpenes when it comes to therapeutic effects. However, as with most cannabis-related areas, a lot of research needs to be done to ensure the effectiveness of this terpene against medical concerns. 

Popular Strains with Caryophyllene Terpene

There are a lot of strains that possess this terpene. However, we have listed some of the Caryophyllene-dominant cannabis strains that you can opt for.

Glue-On Fire

This product by Fleur is among the fan-favorites. Avid cannabis users love to opt for it, mainly because of its terpene profile. Glue on Fire was made by crossing Face on Fire and CG #4. It contains around 20.06% THC, which leaves you with mildly psychoactive effects. Glue on Fire is also known for its relaxing effects on your body, making it a good alternative to opt for after a tiring day.

Fruit Pie 

Fruit Pie by BaM is another Caryophyllene-dominant cannabis product. It comprises over 25% THC coupled with 0.05% CBD. This strain is a cross between Lemon Lime Orange Apricot and the Wedding Pie. It is an Indica-Dominant hybrid and has recently become a fan-favorite for all types of cannabis users.

Gorilla Glue 

If you’re looking for the best Caryophyllene-dominant cannabis products, Gorilla Glue is what you’re looking for. It contains 19.49% THC, and is made from premium hand-picked flowers. Gorilla Glue also contains a couple of other terpenes, including Limonene and Humulene. 

Where to Buy Cannabis in Las Vegas?

Inyo is the best Vegas dispensary to get top-grade cannabis strains and products. We offer a broad range of products both online and in-store. 

You can order online from Monday to Saturday between 9am and 10pm, and on Sundays between 9am and 8pm.

You can also visit our Las Vegas strip dispensary from Monday to Wednesday between 8am and 12am, from Thursday to Saturday from 8am and 2am, on Sunday from 8am to 10pm.

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